Pearay L Ogra, MD
State University of New York
Women and Children’s Hospital
219 Bryant Street, Buffalo, NY, 14222
Ogra’s career in academic medicine began in the early 1960’s. His clinical, research, administrative and academic leadership has largely focused on Pediatric Vaccines and prevention of childhood infections, mucosal vaccine development, and definition of biologic markers of immunity against human viral and bacterial infections. His earlier investigative effort was directed towards Poliovirus-specific host-pathogen interactions, efficacy of live and inactivated poliovirus vaccines, and cellular and molecular aspects of mucosal immunity. His major scientific contributions began with the first functional characterization of secretory IgA and “alimentary” mucosal immunity. In subsequent series of investigations, he defined the role of secretory IgA and cellular mucosal immune responses to such human infections as rubella, mumps, hepatitis B virus and enteroviruses. Subsequently, his laboratory provided extensive immunologic characterization of human milk, its role in maternal-neonatal interactions and childhood infections, and the association of mammary glands with other components of the common mucosal immune system. Other investigations from his laboratory and from his colleagues have identified important components of host-pathogen interactions underlying the pathogenesis of mucosal infections, notably in Bronchiolitis due to respiratory syncytial virus (RSV), gastroenteritis due to rotavirus, and immunologic aspects of Otitis media in childhood. These include, demonstration of RSV specific IgE in the respiratory mucosa and its role in viral induced reactive airway disease, identification of rotavirus- specific receptor-binding sites in villous enterocytes in early infancy and the role of Bifidobacteria in modulating rotavirus-mucosal cell interactions, and development of IgA and other aspects of mucosal immune responses in the middle ear mucosa during otitis media.
In 1990, he was appointed as the John Sealy Distinguished Chair Professor and Chairman of the Department of Pediatrics at the University of Texas Medical Branch (UTMB), Galveston, Texas. In this role, he was also the Pediatrician-in-Chief at the UTMB Children's Hospital, and served as Professor of Microbiology and Immunology. During his tenure as the chairman, the department underwent immense growth in several academic areas. These include: a 10-fold increase in the Federal research funding in the department, a new research program funded by NICHD to establish one of the first Child Health Research Centers in the Departments of Pediatrics, and the establishment of a full service Children’s Hospital in Galveston. At the time of his retirement from the chair at UTMB, the department of Pediatrics had established four endowed professorships and an active NIH funded program in child health. He retired from this position in 2002. Since that time, he has returned to the Children’s Hospital of Buffalo. He is currently serving as Professor Emeritus, Department of Pediatrics at the State University of New York at Buffalo.
OTHER ACADEMIC CREDENTIALS
Elected to over 30 national and international scientific societies,
including the following:
Awards and Honors:
National and International Advisory Panels:
World Health Organization
National Institutes of Health
Institute of Medicine:
National academy of Sciences
Federal Drug Administration
International Vaccine Institute, Seoul, S. Korea.
Chairman, External Review Group.
International pediatric research foundation, Inc.
Old Herborn University, Germany
Pharmaceutical Advisory Boards
Ross Nutrition Conferences: Mucosal Immune system in Health and
To date, Dr. Ogra has contributed over 440 peerreviewed original scientific publicationsand review articles. He has edited, in collaborations with many of his colleagues, 19 full-length books and monographs. He has served as the founding editor of the first comprehensive textbook of Mucosal Immunology. The latest editions of this text were dedicated to him by the current editors.
During his investigative career, Dr. Ogra has served as the principal mentor during the training of over 75post-doctoral fellows and PhD studentsin Microbiology and Immunology and has been involved in the training of over 500 Pediatric residentsboth in New York and in Texas.
Dr. Ogra was born in Kashmir, India. He obtained his early education in Srinagar, Kashmir and the Medical degree from the Christian Medical College, Ludhiana, Punjab, India. Subsequently, Dr. Ogra received residency and post-doctoral training in Pediatrics, Infectious Diseases, Clinical Virology and Immunology at the Upstate Medical center-Binghamton General Hospital, University of Chicago-Bob's Roberts Children's Hospital, New York University-Bellevue Medical Center, and at the State University of New York at Buffalo respectively.
He continues to remain very active as a consultant and teacher in the diverse spectrum of vaccine research and development and in the global issues of childhood infectious diseases. He devotes significant amount of his effort in the field in South Asia, towards the control of vaccine preventable diseases of the poor.