P. L. Ogra

  

Pearay L Ogra, MD

Professor Emeritus

State University of New York

Women and Children’s Hospital

219 Bryant Street, Buffalo, NY, 14222

Ogra’s career in academic medicine began in the early 1960’s. His clinical, research, administrative and academic leadership has largely focused on Pediatric Vaccines and prevention of childhood infections, mucosal vaccine development, and definition of biologic markers of immunity against human viral and bacterial infections. His earlier investigative effort was directed towards Poliovirus-specific host-pathogen interactions, efficacy of live and inactivated poliovirus vaccines, and cellular and molecular aspects of mucosal immunity. His major scientific contributions began with the first functional characterization of secretory IgA and “alimentary” mucosal immunity. In subsequent series of investigations, he defined the role of secretory IgA and cellular mucosal immune responses to such human infections as rubella, mumps, hepatitis B virus and enteroviruses. Subsequently, his laboratory provided extensive immunologic characterization of human milk, its role in maternal-neonatal interactions and childhood infections, and the association of mammary glands with other components of the common mucosal immune system. Other investigations from his laboratory and from his colleagues have identified important components of host-pathogen interactions underlying the pathogenesis of mucosal infections, notably in Bronchiolitis due to respiratory syncytial virus (RSV), gastroenteritis due to rotavirus, and immunologic aspects of Otitis media in childhood. These include, demonstration of RSV specific IgE in the respiratory mucosa and its role in viral induced reactive airway disease, identification of rotavirus- specific receptor-binding sites in villous enterocytes in early infancy and the role of Bifidobacteria in modulating rotavirus-mucosal cell interactions, and development of IgA and other aspects of mucosal immune responses in the middle ear mucosa during otitis media.

In 1990, he was appointed as the John Sealy Distinguished Chair Professor and Chairman of the Department of Pediatrics at the University of Texas Medical Branch (UTMB), Galveston, Texas. In this role, he was also the Pediatrician-in-Chief at the UTMB Children's Hospital, and served as Professor of Microbiology and Immunology. During his tenure as the chairman, the department underwent immense growth in several academic areas. These include: a 10-fold increase in the Federal research funding in the department, a new research program funded by NICHD to establish one of the first Child Health Research Centers in the Departments of Pediatrics, and the establishment of a full service Children’s Hospital in Galveston. At the time of his retirement from the chair at UTMB, the department of Pediatrics had established four endowed professorships and an active NIH funded program in child health. He retired from this position in 2002. Since that time, he has returned to the Children’s Hospital of Buffalo. He is currently serving as Professor Emeritus, Department of Pediatrics at the State University of New York at Buffalo.

OTHER ACADEMIC CREDENTIALS

Elected to over 30 national and international scientific societies,

including the following:

  • Association of American Physicians
  • American Society for Clinical Investigation
  • Society for Pediatric research
  • American Pediatric Society
  • Fellow Royal Society (Medicine) UK . (FRS M),
  • Fellow Infectious Diseases Society of America (FIDSA)
  • Fellow American Academy of Microbiology (FAAM)
  • Fellow American academy of Pediatrics (FAAP)

Awards and Honors:

  • E. Mead Johnson Award: American Academy of Pediatrics for outstanding research in Pediatrics.
  • Stockton Kimball Award: State University of New York for outstanding scientific contributions
  • Outstanding Scientific contributions award: The Association of Asian American Physicians.
  • Merck Scholar-in-Residenceat the International vaccine Institute, a United Nations Chartered Institute based in Seoul, Korea.
  • Guest of Honor and Commencement speakerat the 2010 graduation ceremonies at his Alma mater, the Christian Medical College in Ludhiana, India
  • Kalhana Award: Kashmir cultural and scientific society

National and International Advisory Panels:

World Health Organization

  • Committees on Respiratory Diseases
  • Committee on Reproductive Medicine
  • Conference Chair: Global Control of Poliomyelitis and Development of poliovirus specific Mucosal Immunity, New Delhi
  • Steering Committee on Measles and Acute Respiratory Diseases.

National Institutes of Health

  • Laboratory for Clinical Investigation – NIAID
  • National Institute of Environmental Health Science – NIH
  • Maternal and Child Health Research Committee – NICHHD
  • Virology Study section

Institute of Medicine:

National academy of Sciences

  • Advisory committee. vaccines for the 21stcentury

Federal Drug Administration

  • FDA Committee on Vaccines

International Vaccine Institute, Seoul, S. Korea.

  • Scientific Advisory Board member

European Union

  • Mucosal Vaccine Development Program (MUVAPRED)

Chairman, External Review Group.

International pediatric research foundation, Inc.

  • Chairman of the Board responsible for ; Pediatric Researchjournal.

Old Herborn University, Germany

  • Symposium Series Scientific Advisory Board

Pharmaceutical Advisory Boards

  • Merck & Co. Scientific Advisory Board for Human Papilloma Virus (HPV) Vaccine
  • Novartis Inc.: Scientific Advisory Panel. Use of Meningococcal Vaccines in the USA.
  • Nestle Nutrition workshop series. Co-Chairman and Editor: Workshop 61, Window of Opportunity: Pre-pregnancy to 24 months of age.
  • Ross-Abbott Laboratories. Nutrition and breast feeding;

Ross Nutrition Conferences: Mucosal Immune system in Health and

Disease

To date, Dr. Ogra has contributed over 440 peerreviewed original scientific publicationsand review articles. He has edited, in collaborations with many of his colleagues, 19 full-length books and monographs. He has served as the founding editor of the first comprehensive textbook of Mucosal Immunology. The latest editions of this text were dedicated to him by the current editors.

During his investigative career, Dr. Ogra has served as the principal mentor during the training of over 75post-doctoral fellows and PhD studentsin Microbiology and Immunology and has been involved in the training of over 500 Pediatric residentsboth in New York and in Texas.

Dr. Ogra was born in Kashmir, India. He obtained his early education in Srinagar, Kashmir and the Medical degree from the Christian Medical College, Ludhiana, Punjab, India. Subsequently, Dr. Ogra received residency and post-doctoral training in Pediatrics, Infectious Diseases, Clinical Virology and Immunology at the Upstate Medical center-Binghamton General Hospital, University of Chicago-Bob's Roberts Children's Hospital, New York University-Bellevue Medical Center, and at the State University of New York at Buffalo respectively.

He continues to remain very active as a consultant and teacher in the diverse spectrum of vaccine research and development and in the global issues of childhood infectious diseases. He devotes significant amount of his effort in the field in South Asia, towards the control of vaccine preventable diseases of the poor.



Explore all Chapters
  • + THE FIELD OF PEDIATRICS (2)
  • + GROWTH, DEVELOPMENT AND BEHAVIOR (5)
  • + PSYCHOLOGIC DISORDERS (9)
  • + CHILDREN WITH SPECIAL NEEDS (2)
  • + NUTRITION (3)
  • + THE PATHOPHYSIOLOGY OF BODY FLUIDS (0)
  • + PEDIATRIC DRUG THERAPY (11)
  • + THE ACUTELY ILL CHILD (4)
  • + HUMAN GENETICS (0)
  • + METABOLIC DISEASES (1)
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