For healthy children ≤12 years, varicella is typically self-limited and antiviral therapy is not required.
Oral Antiviral Therapy (Acyclovir or Valacyclovir)is suggested for 5-7 days duration in following scenarios as a pre-emptive measure to prevent complications-
Intravenous Acyclovir should be initiated and is given for a longer duration i.e. 7-10 days for individuals who present at any Age with complications (eg pneumonitis, encephalitis) related to varicella or are immunocompromised (HIV or any other accquired or congenital Immunodeficiency, on Immunosuppressive medications, taking systemic steroids for > 2 weeks, etc).
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