Beta thalassemia is a hereditary anemia characterised by reduced or complete absence of β- globin chain synthesis and the manifestations are the result of precipitation of excessive unpaired α- globin chain.
Thalassemia major refers to disease requiring more than eight red blood cell transfusions per year and thalassemia intermedia, to disease that requires no or infrequent transfusions. Thalassemia minor/trait refers to carrier of one mutation (heterozygous) and these individuals have no or only mild anemia.
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