While acid-suppression medications are necessary in infants with GERD, but many times, its seen that these medications are being used to treat newborn reflux, which may be a normal newborn behavior. Recent comparison studies suggest that PPI initiation at 0 to 6 months of life was associated with a 23% increased fracture risk while the increase in risk was 21% when PPIs were introduced at age of 6 to 12 month. The risk also appeared to increase with increasing duration of acid-suppression therapy.
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