Neonatal cholestasis is defined as jaundice with high color urine staining diaper in an infant within first 3 months of life.
The common causes of neonatal cholestasis are –
1) Extra hepatic – biliary atresia, choledocal cyst
2) Intrahepatic – Idiopathic Neonatal Hepatitis (INH)
3) Infectious - TORCH infection
4) Metabolic – Galactosemia, Tyrosinemia, etc.
It should be kept in mind that Idiopathic Neonatal Hepatitis (INH) which is the most common cause of neonatal cholestasis is a diagnosis of exclusion. Its diagnosis can be confirmed only by excluding other causes of cholestasis and these children improve completely on follow up.
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