Pediatric Systemic Lupus Erythematosus(pSLE) is a multisystemic connective tissue disease which is seen more commonly in females. A multisystemic approach to history, examination and investigations should be followed.
Common clinical features suggestive of pSLE are prolonged fever, photosensitivity, malar rash, recurrent oral ulcers, Raynaud’s phenomenon(Bluish discoloration of fingers on cold exposure), arthritis and serositis. Renal involvement (proteinuria, hematuria or urinary casts) is seen in upto 60-80% of the patients.
Laboratory findings which can be seen in pSLE are elevated ESR, cytopenias, hemolytic anemia, hypergammaglobulinaemia and hypocomplementemia(low C3 and C4). Antinuclear antibody(ANA) is positive in almost all of the patients. Patients suspected with pSLE should be referred to a pediatric rheumatologist
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