Select the least toxic aminoglycoside when possible, adjust the dose for renal function.
Limit the duration of therapy to 7 to 10 days.
Once daily dose regimen in preferably intravenous infusion or intramuscular administration should be used.
Direct IV bolus should never be administered.
Ensure adequate hydration of the child and minimize concomitant nephrotoxic medications. Correct hypokalemia prior to aminoglycoside dose as possible. Monitor renal functions & avoid in patients with liver disease.
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