In a systematic review of randomized controlled trials and meta-analysis (2013) the results showed that children who received antipyretics (acetaminophen , ibuprofen or diclofenac ) and placebo for prevention of subsequent febrile seizures upto a period of 2 years follow-up showed, 22.7% patients in the antipyretics group and 24.4% in the placebo group had febrile seizure recurrence. No statistically significant difference was found between the antipyretics and the placebo groups leading to conclusion that Antipyretics are ineffective in reducing the recurrence of febrile seizures.
Given the benign nature of recurrent febrile seizures parents and families should be supported with adequate contact details of medical services and information on recurrence, first aid management and, most importantly, the benign nature of the phenomenon
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