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Pediatric Hematology Oncology

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  • Lymphopenia in a newborn or infant is perhaps the most important indicator for urgent referral to a higher centre. Often absolute lymphocyte count is ignored in a differential count as emphasis is mainly given to total WBC and neutrophil count. Most patients with severe combined immunodeficiency are lymphopenic at birth and they are uniformly fatal before 1 year of age unless definitive therapy is instituted.
  • Lymphocytosis is usually a feature of viral infections and rarely points to PIDs.
  • Persistent Eosinophilia is observed in primary immunodeficiencies including Hyper IgE syndromes.
  • Monocytopenia also has been defined with primary immunodeficiencies with susceptibility to mycobacterial, fungal and viral infections.
  • Platelet Counts - In PIDs, thrombocytopenia has been observed as a direct effect of the disease or as a feature of autoimmunity.
  • Anemiais commonly observed in many immunodeficiencies as a result of repeated infections and malabsorption.

Posted On: 22/01/2019

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