Paracetamol (acetaminophen) is considered the safest of all the antipyretic drugs. It is recommended that a combination of two drugs and sequential use should be avoided. There is some evidence that both alternating or combined antipyretic therapy may be more effective at reducing temperatures than mono-therapy alone.However, the evidence for improvement in child discomfort remains inconclusive.There is insufficient evidence to know which of combined or alternating therapy might be more beneficial.
Cough-and-cold products that contain paracetamol/acetaminophen and ibuprofen should not be given to children because of the possibility that parents may unintentionally give their child simultaneous doses of an antipyretic and a cough-and-cold medication containing the same antipyretic.
In USA mefenamic acid is not approved for children less than 14 year of age.
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