Topical calcineurin inhibitors ( Tacrolimus/Pimecrolimus)are complexmacrolide compounds and selectively inhibit cytokine transcription in activated T-cells
Tacrolimus is used in chronic extensive atopic dermatitis as steroid sparing agents; also do not cause skin atrophy, they are useful for facial and eyelid dermatitis.
Tacrolimus 0.1% ointments are safe in children >2years of age.
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