Most of these individuals are asymptomatic, do not require any treatment and have normal life span. Their peripheral smear shows microcytosis and hypochromia (MCV < 80 fl and MCH <27 pg), with RBC count higher for a given Hb concentration.
Mentzer index - MCV/RBC count: Value < 13 suggests thalassemia minor and >13 suggests iron deficiency anemia
HPLC or Hemoglobin electrophoresis confirms the diagnosis when HbA2 is more than 3.5%
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