Primary immunodeficiencies are to be suspected in any patient with (i)unusual susceptibility for infections, (ii)severe or early onset autoimmunity and (iii)susceptibility to malignancies. Initially only patients with susceptibility towards infections were evaluated for primary immunodeficiencies. For this purpose, a set of warning signs were suggested by Jeffrey Model Foundation, USA which included recurrent infections, severe infections requiring intravenous antibiotics, unusual infections as well as significant family history. The warning signs can be easily accessed online.
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