Any new born with jaundice and dark yellow urine staining the diaper, with or without pale stools, should be strongly suspected to have Neonatal Cholestasis.
Biliary Atresia usually presents with jaundice with diaper staining in an otherwise healthy well thriving baby.
Metabolic disorders commonly present with cholestasis with decompensation like bleeding, ascites and coagulopathy like galactosemia, tyrosinemia and neonatal hemochromatosis.
A detailed history and clinical examination helps to narrow down the differential diagnosis and focus investigation to confirm the diagnosis
Every infant with cholestasis needs early referral to Pediatric Gastroenterologist for evaluation of under laying cause without delay.
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